Research & Evidence
The scientific foundation for hydrogen therapy is substantial and growing. Below is a summary of key research milestones:
1975 — Dole et al. first demonstrated potential of H₂ in treating skin cancer, marking the introduction of H₂ as a therapeutic tool.
2007 — Ohsawa et al. published a landmark study in Nature Medicine demonstrating that 2% H₂ gas selectively scavenges hydroxyl radicals and peroxynitrite, dramatically reducing brain damage from ischemia-reperfusion injury in rats. This paper launched the modern era of hydrogen medicine.
2008 — Nakao et al. confirmed H₂ inhalation improved transplant-related intestinal injury by inhibiting oxidative stress.
2016 — Japan approved H₂ inhalation therapy as an emergency treatment for cardiopulmonary arrest under Advanced Medical Care B.
2020 — China's National Health Commission recommended H₂/O₂ inhalation in the official 7th edition guidelines for COVID-19 treatment.
2021–2025 — Hundreds of peer-reviewed publications have expanded the evidence base across pulmonary disease, neurological disease, cancer, cardiovascular conditions, sepsis, aging, and metabolic disorders.
